A 13-year-old female barred owl (Strix varia) presented for anorexia and lethargy. Physical examination revealed obesity, and radiographs demonstrated hepatomegaly. Plasma biochemistry values suggested liver disease, and hepatic lipidosis was confirmed by liver biopsy. Treatment included antibiotic and antifungal therapy, fluid administration, vitamin supplementation, and enteral alimentation with a balanced diet delivered through an esophagostomy tube. The owl completely recovered within 78 days after initial presentation.